- Sega Genesis Classic Collection: Gold Edition
- SEGA Rally Online Arcade
- Sega Superstars Tennis
- Selknam Defense
- Sengoku Basara 4
- Sengoku Basara: Samurai Heroes
- Sengoku Dynasty
- Sengoku [II/2011]
- Senran Kagura 2: Deep Crimson
- Senran Kagura: Bon Appétit!
- Senran Kagura Burst
- Senran Kagura Burst: Crimson Girls
- Senran Kagura: Estival Versus
- Senran Kagura: Peach Ball
- Senran Kagura: Peach Beach Splash
- Senran Kagura Reflexions
- Senran Kagura: Skirting Shadows
- Sensei Wars
- Sentinel 4: Dark Star
- Sentry
- Sequence
- Seraph
- Serial Cleaners
- Serious Sam
- Serious Sam 2
- Serious Sam 3: BFE
- Serious Sam 4
- Serious Sam Collection, The
- Serious Sam HD: The First Encounter
- Serious Sam HD: The Second Encounter
- Serious Sam: Kamikaze Attack!
- Serious Sam: Next Encounter
- Serious Sam: Siberian Mayhem
- Serious Sam: The Random Encounter
- Serious Sam VR: The Last Hope
- Serious Sam's Bogus Detour
- Serum
- Servo
- Sesame Street: Elmo's Musical Monsterpiece
- Sesame Street: Once Upon a Monster
- Settlement: Colossus
- Settlers 4 Mission Pack, The
- Settlers 7: Paths to a Kingdom, The
- Settlers: Fourth Edition, The
- Settlers: Heritage of Kings, The
- Settlers: Kingdoms of Anteria, The
- Settlers: New Allies, The
- Settlers Online, The
- Settlers: Rise of an Empire, The
- SEUM: Speedrunners from Hell
- Seven Dragon Saga
- Seven Kingdoms: Conquest
- Seven Souls Online
- Seven: The Days Long Gone
- Sevencore
- Severed
- Sexy Beach Premium Resort
- Sexy Brutale, The
- Shadow Blade
- Shadow Empire
- Shadow Fight 2
- Shadow Fight 3
- Shadow Harvest: Phantom Ops
- Shadow Heroes: Vengeance in Flames
- Shadow Man: 2econd Coming
- Shadow Man: Remastered
- Shadow Move
- Shadow of a Soul: Chapter 1
- Shadow of Conspiracy: Section 2
- Shadow of the Beast [II/2016]
- Shadow of the Colossus
- Shadow of the Eternals
- Shadow of the Game
- Shadow of the Tomb Raider
- Shadow of the Tomb Raider: The Forge
- Shadow of the Tomb Raider: The Price of Survival
- Shadow Ops: Red Mercury
- Shadow Realms
- Shadow Tactics: Blades of the Shogun
- Shadow Tactics: Blades of the Shogun - Aiko's Choice
- Shadow Warrior 2
- Shadow Warrior 3
- Shadow Warrior [I/1997]
- Shadow Warrior [II/2013]
- Shadowgate [II/2014]
- Shadowgun
- Shadowgun: Legends
- Shadowgun War Games
- Shadowland Online
- Shadowplay: Metropolis Foe
- Shadowrun Chronicles: Boston Lockdown
- Shadowrun: Dragonfall
- Shadowrun: Hong Kong
- Shadowrun [IV/2007]
- Shadowrun Returns
- Shadows: Awakening
- Shadows: Heretic Kingdoms
- Shadows of Kurgansk
- Shadows of the Damned
- Shadows of War